张大海

张大海

职称：

教授

办公电话：

+86-532-6678-2215

个人邮箱：

dahaizhang@ouc.edu.cn

研究领域或方向：

专业:

天然产物化学、污染物生物降解、污水微生物处理、特殊功能材料改性分析

特长:

DNA提取与分离、分析

深海热液出口微生物的提取、培养

共生关系研究

污水微生物处理

谱图解析、化合物结构解析、天然产物化学、生物修饰

水热合成无机材料及分析

教育与研究经历：

2011.7-教师，海洋化学理论与工程技术教育部重点实验室/化学化工学院中国海洋大学

2010.4-2011.7ICBB项目研究员，俄勒冈州立大学，科瓦利斯，美国

2010.4-2011.3“Deep Sea Vent”项目研究员，俄勒冈州立大学，科瓦利斯，美国

2008.3-2010.3Global Center Of Excellence Researcher访问学者，东京大学理学部，东京，日本

2004.9-2008.3博士研究生，化学化学工学院，中国海洋大学

2005.9-2007.8博士研究生，釜庆国立大学化学系，釜山，韩国

2001.9-2004.7硕士研究生，化学化学工学院，中国海洋大学

1997.9-2001.7本科，高分子材料与工程系，西北工业大学，西安，中国

1998.9-2000.7辅修专业，国际经济与贸易系，西北工业大学，西安，中国

学术兼职：

Ø 青岛市分析测试学会科技成果标准化评价办公室主任

Ø 青岛市分析测试学会色谱委员会委员

主持或参与的项目：

1、韩国某政府部门资助的“BK21”系列项目，负责真菌的分离、纯化及其活性测试

2、日本文部省Global Center Of Excellence资助的“珊瑚及其内生海洋真菌间共生关系研究”项目

3、美国俄勒冈海基金（DSV）资助的“深海热液出口微生物研究”项目

4、俄勒冈州立大学药学院基金（ICBB）资助的美印合作“ICBB稀有陆地来源真菌、细菌的分离、纯化及其代谢产物研究”项目

5、中国海洋大学海洋化学工程与技术教育部重点实验室资助“南海深海底泥中真菌及其生态关系研究”项目

6、中国海洋大学资助“南海深海底泥来源真菌的提取及其代谢产物研究”项目

7、教育部资助“黄河三角洲盐沼湿地互花米草内生真菌及其共生关系研究”项目

8、青岛市科委资助“壬基酚在胶州湾主要径流河口底泥来源真菌中的生物转化”

9、自然科学基金委资助“沙尘天气对近海大气中生物气溶胶粒径分布和微生物活性及群落结构的影响”子课题：沙尘气溶胶中可培养微生物及其相关性研究

10、博士后基金委资助“河口底泥来源真菌对有机环境毒素壬基酚的降解研究”项目

11、某企业合作项目“热水器水质和结垢、腐蚀相关技术研发”I期

12、某企业合作项目“热水器水质和结垢、腐蚀相关技术研发”II期

13、某企业合作项目“企业生产污水处理关键技术”I期

14、某企业合作项目“企业生产污水处理关键技术”II期

学术成果：

已经取得的研究工作成绩：

作为第一作者、共同作者、通讯作者发表文章40多篇，其中SCI收录20多篇，拥有中国授权专利1项；先后参加韩国、日本、美国、中国学术会议10余次，做特邀大会报告2次，大会报告1次，中国海洋大学优秀博士论文一等奖，获得韩国生药学会年会优秀奖，青岛市分析测试学会优秀论文一、二、三等奖多次。

参加会议、发表的主要文章：

1.韩晨,谢绵测,祁建华,张文倩,李先国,张大海*.青岛市不同空气质量下可培养生物气溶胶分布特征及影响因素[J].环境科学研究，2016, 29(9): 000-000.

2.Yan Zhang, Ying Liu, Han Dong, Xianguo Li, Dahai Zhang*. The nonylphenol biodegradation study by estuary sediment-derived fungusPenicillium simplicissimum. Environmental Science and Pollution Research, 2016, 23: 15122-15132.

3.Jiafu Li, Han Dong, Xiang Xu, Bin Han, Xianguo Li*, Chenjian Zhu, Chen Han, Shaopeng Liu, Dandan Yang, Qian Xu, Dahai Zhang*. Prediction of the bioaccumulation of PAHs in surface sediments of Bohai Sea, China and quantitative assessment of the related toxicity and health risk to humans. Marine Pollution Bulletin, 2016, 104（1-2)：92-100.

4.谢绵测，雷静，李戈辉，孔令萍，李先国，张大海*.响应面法在海洋来源梅花状青霉LGT201107抗氧化活性物质代谢过程优化中的应用研究.中国海洋药物，2016, 35(3): 87-92.

5.陈志香,李先国,张大海*.低分子醇-盐-水相体系在草甘膦母液资源化过程中的应用研究.现代化工，2016，36(5): 110-113.

6.Jiafu Li,Han Dong, Xianguo Li, Bin Han, Chenjian Zhu,Dahai Zhang*. Quantitatively assessing the health risk of exposure to PAHs from intake of smoked meats. Ecotoxicology and Environmental Safety, 2016, 124: 91–95.

7.Xiaoyong Duan, Yanxia Li, Xianguo Li, Yi Gao,Dahai Zhang*. Changes in terrestrial organic matters and pollutants input to the Yangtze River Estuary, East China Sea, during the past century. Envirmental Chemistry, 2016, 13, 631-640.

8.Jiafu Li, Han Dong,Dahai Zhang, Bin Han, Chenjian Zhu, Shaopeng Liu,XiangminLiu,QianyaoMa, Xianguo Li.Sources and ecological risk assessment of PAHs in surface sediments from Bohai Sea and northern part of the Yellow Sea, China.Marine Pollution Bulletin,2015, 96: 485-490.

9.董涵，马燕燕，张大海*等.河口底泥来源真菌Trichoderma asperellum对壬基酚的降解途径,海洋环境科学.2015，34（6）：852-857.

10.谢绵测，李先国，张大海*. OSMAC策略及其在烟曲霉菌次级代谢产物研究中的应用，天然产物研究与开发，2015，27（9）：1668-1673。

11.韩晨，祁建华，张大海*等.青岛近海春季沙尘天空气可培养真菌及其潜在健康风险研究,城市环境与城市生态，2015，28（4）:18-23.

12.邓晓燕，张大海，李先国.气相色谱法测定水体中多环芳烃的前处理方法优化.分析试验室, 2015, 34(5): 525-528.

13.王国光，张大海,杨丹丹,彭佳琳,李先国.超声辅助碱解萃取－气相色谱－电子捕获检测器测定海洋沉积物中8种多溴联苯醚.色谱，2015, 33(8): 885-891.

14.梁贞,张大海,王敏等.东海泥质区中木质素的分布特征及其指示意义.海洋环境科学.2014, 33（4）：509-513, 530.

15.李孟芳，张大海，段晓勇等.南黄海表层沉积物中邻苯二甲酸酯的分布特征.海洋环境科学2014, 33（5）:682-687.

16.Xiaoyong Duan, Yanxia Li, Xianguo Li,Dahai Zhang.Alkylphenols in surface sediments of the Yellow Sea and East China Sea inner shelf: Occurrence, distribution and fate.Chemosphere, 2014, 107: 265–273.

17.Xiaoyong Duan, Yanxia Li, Xianguo Li,Dahai Zhang. Distributions and sources of polychlorinated biphenyls in the coastal East China Sea sediments.Sci. Total Environ., 2013, 463-464: 894-903.

18.Xiaoyong Duan, Yanxia Li, Xianguo Li, Dahai Zhang. Polychlorinated biphenyls in sediments of the Yellow Sea: Distribution, source identification and flux estimation. Mar. Pollut. Bull., 2013, 76(1-2): 283-290.

19.Wei Deng, Xianguo Li, Shengyong Li,Dahai Zhang. Source Apportionment of Polycyclic Aromatic Hydrocarbons in Surface Sediment of Mud Areas in the East China Sea Using Diagnostic Ratios and Factor analysis.Mar. Pollut. Bull., 2013, 70(1-2): 266-273.

20.李先国,马燕燕，张大海.壬基酚生物降解研究进展，中国海洋大学学报，2013，43（5）：64-69.

21.李先国，马燕燕，董涵，刘莹，张大海.两株河口底泥来源真菌对壬基酚降解特性初探,青岛市分析测试学会，2012年度优秀学术论文二等奖，2013.1.

22.张大海*，徐香，李先国，刘莹，董涵.海葵内生真菌来源天然产物蛇胞菌素的构效关系解析,青岛市分析测试学会，2012年度优秀学术论文一等奖，2013.1.

23.Dahai Zhang*, Seketsu Fukuzawa, Masayuki Satake, Xianguo Li, Takafumi kuranaga, Ai Niitsu, Kentaro Yoshizawa, and Kazuo Tachibana*. Ophiobolin O and 6-epi-ophiobolin O, Two New Cytotoxic Sesterterpenes, from Marine Derived FungusAspergillussp.Nat. Prod. Comm.2012, 7(11): 1411-1414.

24.Dahai Zhang*, Seketsu Fukuzawa, Kohtaro Sugahara, Ai Niitsu, Tomohiro Shirai, Masayuki Satake and Kazuo Tachibana*. Two new cytotoxic indole alkaloids, 2-(dimethylprop-1-ene)-costaclavine and 2-(dimethylprop-1-ene)-epicostaclavine from the marine-derived fungusAspergillus fumigatus,J. Nat. Med.2012, 66(1): 222-226.

25.张大海*，Edward Mitchell，刘莹，李先国，Christopher C. Thornburg，Mark Zabriskie，Kerry L. McPhail*.美国俄勒冈州外深海热液出口周边微生物研究方法初探.第二届环渤海色谱学术报告会,2012.9,中国青岛.

26.张大海*，Edward Mitchell，刘莹，李先国，Christopher C. Thornburg，Mark Zabriskie，Kerry L. McPhail*.美国俄勒冈州外深海热液出口周边微生物研究方法初探.山东大学学报，2012, 47（S2）:84-86.

27.Justyna Sikorska,Dahai Zhang, Christopher C. Thornburg, Edward A. Mitchell, William W. Chadwick Jr., David A. Butterfield, Mark T. Zabriskie, Jane E. Ishmael, and Kerry L. McPhail*. Cytotoxic constituents of exophiala xenobiotica, fungus isolated from deep-see hydrothermal vents. SMASH 2011, Chamonix, France.

28.Dahai Zhang*, Xianguo Li, Seketsu Fukuzawa, Masayuki Satake and Kazuo Tachibana*. Two new cytotoxic indole alkaloids, 2-(dimethylprop-1-ene)-costaclavine and 2-(dimethylprop-1-ene)-epicostaclavine from the marine-derived fungusAspergillus fumigatus, HPLC2011, Dalian, China.

29.Dahai Zhang*, Xianguo Li, Masayuki Satake, Seketsu Fukuzawa and Kazuo Tachibana*. Ophiobolin O and 6-epi-ophiobolin O, Two New Cytotoxic Sesterterpenes, from Marine Derived FungusAspergillussp. 18thNSEC, 2011, Dalian, China.

30.Dahai Zhang*, Deep-sea vent-derived microorganisms: a new source of medicinally relevant small molecule natural products for future. Guest speaker, The 7thKSMB conference, 2011, Busan, Korea.

31.Dahai Zhang, Deep-sea vent-derived microorganisms: a new source of medicinally relevant small molecule natural products. Invited speaker, The 20thVolcano conference, 2011, Seattle, USA.

32.Dahai Zhang, Christopher C. Thornburg, Edward Mitchell, T. Mark Zabriskie and Kerry L. McPhail*. Deep-sea vent-derived microorganisms, a new source of medicinally relevant small molecule natural products. 2011 Retreat of School of Pharmacy, Oregon State University,Salishan, OR, 97388, USA.

33.Dahai Zhang, Dwi Andreas Santosa, Philip J. Proteau, T. Mark Zabriskie and Taifo Mahmud*. New antibiotic drug discovery: exploration of microorganisms from unique ecosystems. 2011 Retreat of School of Pharmacy, Oregon State University,Salishan, OR, 97388, USA.

34.Viviane Nenkep, Keumja Yun,Dahai Zhang, Hong Dae Choi, Jung Sook Kang, and Byeng Wha Son*. Induced production of bromomethylchlamydosporols A and B from the marine-derived fungusFusarium tricinctum.J. Nat. Prod.2010, 73(12), 2061-2063.

35.Xin Han*, Chao Peng, Deshi Ye,Dahai Zhang, and Yan Lan. Dynamic bin packing with unit fraction items revisited.Information Processing Letters, 2010(110), 1049-1054.

36.Feng, Zhile, Viviane N. Nenkep, Keumja Yun,Dahai Zhang, Hong Dae Choi, Jung Sook Kang, and Byeng Wha Son*.Biotransformation of Bioactive (–)-Mellein by a Marine Isolate of BacteriumStappia sp.J. Microbiol. Biotechnol. 2010, 20(6), 985-987.

37.Dahai Zhang, Christopher C. Thornburg, T. Mark Zabriskie and Kerry L. McPhail*. Deep-sea vent-derived microorganisms, a new source of medicinally relevant small molecule natural products. 2010 Retreat of CGRB, Oregon State University,Corvallis, OR, 97331, USA.

38.Dahai Zhang, Xiudong Yang, Jung Sook Kang, Hong Dae Choi, Byeng Wha Son. Chlorohydroaspyrones A and B, Antibacterial Aspyrone Derivatives from the Marine-Derived FungusExophialasp.J. Nat. Prod.2008, 71(8), 1458-1460.

39.Zhang Dahai, Xianguo Li, Jung Sook Kang, Hong Dae Choi,Byeng Wha Son.Redoxcitrinin, a Biogenetic Precursor of Citrinin from Marine Isolate of FungusPenicilliumsp.J.Microbiol. Biotechnol.2007, 17(5), 865-867.

40.Dahai Zhang, Xiudong Yang, Jung Sook Kang, Hong Dae Choi, Byeng Wha Son.Circumdatin I, a New Ultraviolet-A Protecting Benzodiazepine Alkaloid from a Marine Isolate of the Fungus Exophiala.J. Antibiotics,2008,61(1), 40-42.

41.Dahai Zhang, Xianguo Li, Jung Sook Kang, Hong Dae Choi,Byeng Wha Son.A New α-Pyrone Derivative,6-[(E)-Hept-1-enyl]-α-pyrone,with Tyrosinase Inhibitory Activity from a Marine Isolate of the FungusBotrytis.Bull. Korean Chem. Soc. 2007, 28(5), 887-888.

42.Hung Phi Nguyen,Dahai Zhang, Uk Lee,Jung Sook Kang, Hong Dae Choi,Byeng Wha Son.Dehydroxychlorofusarielin B, an Antibacterial Polyoxygenated Decalin Derivative from the Marine-Derived FungusAspergillussp.J.Nat. Prod. 2007, 70(7), 1188-1190.

43.Xifeng Li,Dahai Zhang, Uk Lee, Xianguo Li, Jiagao Cheng, Weiliang Zhu, Jee H. Jung, Hong Dae Choi,Byeng Wha Son.Bromomyrothenone B and Botrytinone, Cyclopentenone Derivatives from a Marine Isolate of the FungusBotrytis.J.Nat. Prod. 2007, 70, 307-309.

44.Chuanhui Gao, Xianguo Li, Lijuan Feng, Zhanchang Xiang,Dahai Zhang. Preparation and thermal decomposition of 5Mg(OH)2MgSO42H2O nanowaskers.Chemical Engineering Journal,2009, 150, 551-554.

45.Feng, Zhile, Viviane N. Nenkep, Keumja Yun,Dahai Zhang, Hong Dae Choi, Jung Sook Kang, and Byeng Wha Son.Biotransformation of Bioactive (–)-Mellein by a Marine Isolate of BacteriumStappia sp.J. Microbiol. Biotechnol. 2010, 20(6), 985-987.

46.Dahai Zhang, Dedi Noviendri, Muhammad Nursid, Xiudong Yang, Byeng Wha Son.Korean Soc. 12,13-Dihydroxyfumitremorgin C, Fumitremorgin C, and Brevianamide F, Antibacterial Diketopiperazine Alkaloids from the Marine-Derived FungusPseudallescheriasp.Natural Product Sciences, 2007, 13(3), 251-254.

47.Guohua Yang, Viviane N. Nenkep, Xavier N. Siwe, Alain S. Leutou, Zhile Feng,Dahai Zhang, Hong Dae Choi, Jung Sook Kang, and Byeng Wha Son. An acetophenone derivative, clavatol, and a benzodiazepine alkaloid, circumdatin A, from the marine-derived fungusCladosporium.Natural Product Science, 2009, 15(3), 130-133.

48.张大海，李先国，孙炳华.葡萄孢菌代谢产物α-吡喃酮酪氨酸酶抑制活性的研究.中国海洋药物. 2008, 3, 35-38.

49.张大海，李先国，孙炳华.天然产物葡萄孢酮立体构型的解析.应用化学. 2008, 25(12), 1425-1429

50.冯丽娟，张大海，李先国.一种多孔氧化镁晶须的制备.中国专利CN, 200510044630.X.