何治宇，男，汉族, 1988年出生, 医学博士，教授，博士生导师。
海洋化学理论与工程技术教育部重点实验室“青年英才第一层次” 岗位。
课题组网站：https://www.x-mol.com/groups/he_zhiyuEmail: hezhiyu@ouc.edu.cn
何治宇于2017年在中山大学中山医学院获得医学博士学位，师从美国哥伦比亚大学教授，美国工程院院士/美国国家医学院院士，生物材料领域顶刊Biomaterials 主编Kam W. Leong 教授; 2016/12-2017/06美国约翰霍普金斯大学访学; 2017/06-2020/01，美国约翰霍普金斯大学（纳米生物技术研究所&材料科学与工程学院）博士后研究员; 合作导师: Hai-Quan Mao 教授; 2020/03-至今，中国海洋大学教授，“青年英才第一层次” 岗位。
研究方向
1. 新型生物可降解、生物安全的功能性高分子聚合物的精密合成及应用；
2. 蛋白/核酸类生物大分子创新口服递送材料和载体的开发与应用；
3. 构建具有多功能、高载药、靶向、缓/控释、环境响应型纳米药物输送载体，重点在抗菌、糖尿病、急性重症疾病、心血管疾病、肿瘤等的应用。
本课题组实验条件优越，设备齐全，国内交流机会甚多。热诚欢迎具有高分子化学、有机化学、药学、生物医学等领域研究背景、学习勤奋刻苦、对科研充满兴趣且具有长远目标的本/硕/博士生加入本课题组！
代表性成果
近5年已累计在领域内知名杂志ACS Nano, Biomaterials, Journal of Controlled Release, ACS Applied Materials & Interface, Nanoscale, Acta Biomaterilia, Advanced Healthcare Materials, Advanced Therapeutics, Biomaterials Science等上发表SCI论文30余篇，第一作者或通讯作者文章发表23篇，其中中科院1区TOP期刊17篇，申请专利（国际、美国、中国）共6项，其中授权4项。
2021年~
30. Wang, Yanan#, Xinyu Song#, Liwei Zhuang#, Haifeng Lang, Liangmin Yu*, Xuefeng Yan, Zhiyu He*. Kinetic control of Phyticacid/Lixisenatide/Fe (III) ternary nanoparticles assembly process for sustained peptide release. International Journal of Pharmaceutics(2021)In Press . 通讯作者，IF: 5.875 JCR 1区&中科院2区 TOP期刊
29. Xinyu Song, Pengyan Liu1, Xiaohu Liu, Yanan Wang, Huichao Wei, Jingwen Zhang, Liangmin Yu*, Xuefeng Yan,Zhiyu He*. Dealing with MDR bacteria and biofilm in the post-antibiotic era: application of antimicrobial peptides-based nano-formulationMaterials Science and Engineering: C 128 (2021) 112318.通讯作者IF: 7.328JCR 1区&中科院1区TOP期刊
28. Yi Zhao, Minju Pu, Yanan Wang, Liangmin Yu*,Xinyu Songand Zhiyu He*.“Application of nanotechnology in acute kidney injury: From diagnosis to therapeutic implications”Journal of Controlled Release 336 (2021) 233-251.通讯作者 IF: 9.776 JCR 1区&中科院1区 TOP期刊
27. Yi Zhao, Minju Pu, Jingwen Zhang, Yanan Wang, Xuefeng Yan, Liangmin Yu* and Zhiyu He*. “Recent advancements of nanomaterial-based therapeuti strategies toward sepsis: bacterial eradication, anti-inflammation and immunomodulation”Nanoscale13(2021) 10726-10747. 通讯作者IF: 7.79 JCR 1区&中科院1区 TOP期刊
26. Nie, Tianqi, Wei Wang, Xiaohu Liu, Yanan Wang, Keyang Li, Xinyu Song, Jingwen Zhang, Liangmin Yu*, Zhiyu He*. “Sustained Release Systems for Delivery of Therapeutic Peptide/Protein”Biomacromolecules 22, no. 6 (2021) 2299-2324. 通讯作者 IF: 6.998 JCR 1区&中科院1区 TOP期刊
25. Zhao, Yi, Long Chen, Yanan Wang, Xinyu Song, Keyang Li, Xuefeng Yan, Liangmin Yu*, and Zhiyu He*. Nanomaterial-based strategies in antimicrobial application: Progress and perspectives. Nano Research.(2021) 通讯作者IF: 8.897 JCR 1区&中科院1区 TOP期刊
24. Wang, Yanan, Chunhui Wang, Keyang Li, Xinyu Song, Xuefeng Yan, Liangmin Yu*, and Zhiyu He*. Recent advances of nanomedicine-based strategies in diabetes and complications management: Diagnostics, monitoring, and therapeutics. Journal of Controlled Release 330 (2021) 618-640.通讯作者 IF: 9.776 JCR 1区&中科院1区 TOP期刊
23. Nie, Tianqi#, Zhiyu He#*, Yang Zhou, Jinchang Zhu, Kuntao Chen, Gregory P Howard, II Minn, Pengfei Zhao, Zaver M Bhujwalla, Hai-Quan Mao, Lixin Liu and Yongming Chen*. “Non-invasive delivery of levodopa-loaded nanoparticles to the brain via lymphatic vasculature to enhance treatment of Parkinson’s disease.” Nano Research(2021) 1-13.共同第一作者&通讯作者 IF: 8.897 JCR 1区&中科院1区 TOP期刊
2020年
22. Chen, Long, Xinyu Song, Fei Xing, Yanan Wang, Yuanzheng Wang, Zhiyu He*, and Li Sun*. A Review on Antimicrobial Coatings for Biomaterial Implants and Medical Devices. Journal of Biomedical Nanotechnology 16, no. 6 (2020) 789-809. 通讯作者 IF: 4.48 JCR 1区&中科院2区
21. Gui, Zaizhi, Jinchang Zhu, Song Ye, Juan Ye, Jiao Chen, Yuanyuan Ling, Xueting Cai, Peng Cao, Zhiyu He*, and Chunping Hu*. Prolonged melittin release from polyelectrolyte-based nanocomplexes decreases acute toxicity and improves blood glycemic control in a mouse model of type II diabetes. International Journal of Pharmaceutics577 (2020) 119071. 通讯作者，IF: 5.875 JCR 1区&中科院2区 TOP期刊
20. Nie, Tianqi#, Zhiyu He*, Jinchang Zhu, Lixin Liu, and Yongming Chen*. One‐Pot Synthesis of PEGylated Lipoplexes to Facilitate Mucosal Permeation for Oral Insulin Gene Delivery. Advanced Therapeutics 3,no. 3 (2020) 2000016. 共同第一作者&通讯作者
19. He, Zhiyu*, Tianqi Nie, Yizong Hu, Yang Zhou, Jinchang Zhu, Zhijia Liu, Lixin Liu, Kam W. Leong, Yongming Chen*, and Hai-Quan Mao*. A polyphenol-metal nanoparticle platform for tunable release of liraglutide to improve blood glycemic control and reduce cardiovascular complications in a mouse model of type II diabetes. Journal of Controlled Release 318 (2020) 86-97. 第一作者&通讯作者 IF: 9.776 JCR 1区&中科院1区 TOP期刊
18. Lyu, Jingtong, Long Chen, Jiqiang Zhang, Xia Kang, Yunjiao Wang, Wenjie Wu, Hong Tang, Jun Wu*, Zhiyu He*, and Kanglai Tang*. A microfluidics-derived growth factor gradient in a scaffold regulates stem cell activities for tendon-to-bone interface healing. Biomaterials Science8(2020) 3649-3663共同通讯作者 IF: 6.843 JCR 1区&中科院2区 TOP期刊
17. Li, Yang, Yimin Niu, Jianhua Zhu, Cuicui Gao, Qunwei Xu, Zhiyu He, Dawei Chen, Ming Xu, and Yang Liu. Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release. Nanoscale 12,no. 4 (2020) 2673-2685. IF: 7.79 JCR 1区&中科院1区 TOP期刊
16. Shi, Huihui, Ming Xu, Jianhua Zhu, Yang Li, Zhiyu He, Yuxia Zhang, Qunwei Xu, Yimin Niu, and Yang Liu. Programmed co-delivery of platinum nanodrugs and gemcitabine by a clustered nanocarrier for precision chemotherapy for NSCLC tumors. Journal of Materials Chemistry B 8, no. 2 (2020) 332-342. IF: 6.331 JCR 1区&中科院2区
2019年
15. Fu, Zailin, Qiaomei Fan, Yang Zhou, Yi Zhao*, and Zhiyu He*. Elimination of Intracellular Calcium Overload by BAPTA-AM-Loaded Liposomes: A Promising Therapeutic Agent for Acute Liver Failure. ACS Applied Materials & Interfaces 11, no. 43 (2019) 39574-39585. 通讯作者 IF: 9.229 JCR 1区&中科院1区 TOP期刊
14. Hu, Yizong, Zhiyu He, Yue Hao, Like Gong, Marion Pang, Gregory P. Howard, Hye-Hyun Ahn et al. Kinetic control in assembly of plasmid DNA/polycation complex nanoparticles. ACS Nano13, no. 9 (2019): 10161-10178. IF: 15.881 JCR 1区&中科院1区 TOP期刊
13. Nie, Tianqi#, Zhiyu He#*, Yang Zhou, Jinchang Zhu, Kuntao Chen, Lixin Liu, Kam W. Leong, Hai-Quan Mao, and Yongming Chen*. Surface Coating Approach to Overcome Mucosal Entrapment of DNA Nanoparticles for Oral Gene Delivery of Glucagon-like Peptide 1. ACS Applied Materials & Interfaces 11, no. 33 (2019) 29593-29603. 共同第一作者&通讯作者 IF: 9.229 JCR 1区&中科院1区 TOP期刊
12. He, Zhiyu, Yizong Hu, Zaizhi Gui, Yang Zhou, Tianqi Nie, Jinchang Zhu, Zhijia Liu et al. Sustained release of exendin-4 from tannic acid/Fe (III) nanoparticles prolongs blood glycemic control in a mouse model of type II diabetes. Journal of Controlled Release 301 (2019) 119-128. 第一作者 IF: 9.776 JCR 1区&中科院1区 TOP期刊
11. Li, Meng-Fan, Zhi-Yu He, Guo-Yan Li, Qing-Zhu Zeng, Dong-Xiao Su, Jing-Lin Zhang, Qin Wang, Yang Yuan, and Shan He. The formation and characterization of antioxidant pickering emulsions: Effect of the interactions between gliadin and chitosan. Food Hydrocolloids 90 (2019) 482-489. IF: 9.147 JCR 1区&中科院1区 TOP期刊
10. Peng, Jing, Long Chen, Kun Peng, Xuewen Chen, Jun Wu*, Zhiyu He*, and Zhou Xiang*. Bone marrow mesenchymal stem cells and endothelial progenitor cells co-culture enhances large segment bone defect repair. Journal of biomedical nanotechnology15, no. 4 (2019) 742-755. 共同通讯作者 IF: 4.48 JCR 1区&中科院2区
9. Chen, Long, Jun Wu, Chengguang Wu, Fei Xing, Lang Li, Zhiyu He*, Kun Peng*, and Zhou Xiang*. Three-dimensional co-culture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells for bone regeneration. Journal of biomedical nanotechnology15, no. 2 (2019) 248-260. 共同通讯作者 IF: 4.48 JCR 1区&中科院2区
2018年
8. Le, Zhicheng, Yantao Chen, Honghua Han, Houkuan Tian, Pengfei Zhao, Chengbiao Yang, Zhiyu He et al. Hydrogen-bonded tannic acid-based anticancer nanoparticle for enhancement of oral chemotherapy. ACS Applied Materials & Interfaces 10, no. 49 (2018) 42186-42197. IF: 9.229 JCR 1区&中科院1区 TOP期刊
7. He, Zhiyu, Yizong Hu, Tianqi Nie, Haoyu Tang, Jinchang Zhu, Kuntao Chen, Lixin Liu, Kam W. Leong, Yongming Chen, and Hai-Quan Mao. Size-controlled lipid nanoparticle production using turbulent mixing to enhance oral DNA delivery. Acta Biomaterialia 81 (2018) 195-207. 第一作者 IF: 8.947 JCR 1区&中科院1区 TOP期刊
6. Tian, Houkuan, Zhiyu He, Chengxin Sun, Chengbiao Yang, Pengfei Zhao, Lixin Liu, Kam W. Leong, Hai‐Quan Mao, Zhijia Liu, and Yongming Chen. Uniform core–shell nanoparticles with thiolated hyaluronic acid coating to enhance oral delivery of insulin. Advanced Healthcare Materials 7, no. 17 (2018) 1800285. IF: 9.933 JCR 1区&中科院1区 TOP期刊
5. He, Zhiyu, Haoyu Tang, Xinru You, Keqing Huang, Arvind Dhinakar, Yang Kang, Qiaoli Yu, and Jun Wu. BAPTA-AM nanoparticle for the curing of acute kidney injury induced by ischemia/reperfusion. Journal of biomedical nanotechnology14, no. 5 (2018): 868-883.第一作者 IF: 4.48 JCR 1区&中科院2区
4. Zhao, Yi#, Zhiyu He#, Hai Gao, Haoyu Tang, Jianhua He, Qing Guo, Wenli Zhang, and Jianping Liu. Fine tuning of core–shell structure of hyaluronic acid/cell-penetrating peptides/siRNA nanoparticles for enhanced gene delivery to macrophages in antiatherosclerotic therapy. Biomacromolecules 19, no. 7 (2018) 2944-2956.共同第一作者 IF: 6.09 JCR 1区&中科院1区 TOP期刊
3. Chen, Xing, Lili Zhao, Yang Kang, Zhiyu He, Fei Xiong, Xiang Ling, and Jun Wu. Significant suppression of non-small-cell lung cancer by hydrophobic poly (ester amide) nanoparticles with high docetaxel loading. Frontiers in Pharmacology9 (2018) 118. IF: 5.81 JCR 2区&中科院2区
2. He, Zhiyu, Zhijia Liu, Houkuan Tian, Yizong Hu, Lixin Liu, Kam W. Leong, Hai-Quan Mao, and Yongming Chen. Scalable production of core–shell nanoparticles by flash nanocomplexation to enhance mucosal transport for oral delivery of insulin. Nanoscale 10, no. 7 (2018): 3307-3319. 第一作者 IF: 7.79 JCR 1区&中科院1区 TOP期刊
2017年
1. He, Zhiyu, Jose Luis Santos, Houkuan Tian, Huahua Huang, Yizong Hu, Lixin Liu, Kam W. Leong, Yongming Chen, and Hai-Quan Mao. Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin. Biomaterials 130 (2017): 28-41. 第一作者 IF: 12.479 JCR 1区&中科院1区 TOP期刊
